Functional clustering of yeast proteins from the protein-protein interaction network
نویسندگان
چکیده
منابع مشابه
Detecting functional modules in the yeast protein-protein interaction network
MOTIVATION Identification of functional modules in protein interaction networks is a first step in understanding the organization and dynamics of cell functions. To ensure that the identified modules are biologically meaningful, network-partitioning algorithms should take into account not only topological features but also functional relationships, and identified modules should be rigorously va...
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Background Oocyte maturity includes nuclear and cytoplasmic maturity, both of which are important for embryo fertilization. The development of oocyte is not limited to the period of follicular growth, and starts from the embryonic period and continues throughout life. In this study, for the purpose of evaluating the effect of the FSH hormone on the expression of genes, GEO access codes for this...
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Protein interactions are central to most biological processes. We investigated the dynamics of emergence of the protein interaction network of Saccharomyces cerevisiae by mapping origins of proteins on an evolutionary tree. We demonstrate that evolutionary periods are characterized by distinct connectivity levels of the emerging proteins. We found that the most-connected group of proteins dates...
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Structural features found in biomolecular networks that are absent in random networks produced by simple algorithms can provide insight into the function and evolution of cell regulatory networks. Here we analyze "betweenness" of network nodes, a graph theoretical centrality measure, in the yeast protein interaction network. Proteins that have high betweenness, but low connectivity (degree), we...
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Comprehensive data of protein interactions are suitable for large-scale identifications of functional units such as protein complexes and pathways. There have been the preceding studies to identify the functional units mainly by graph approaches and by co-expression. In this poster presentation, we propose the evolutionary approaches to identify the functional units in yeast protein interaction...
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ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2006
ISSN: 1471-2105
DOI: 10.1186/1471-2105-7-355